By Osamu Hayaishi
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Additional resources for ADP-Ribosylation Reactions. Biology and Medicine
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2. Conformation of Ado(P)-Rib-P Poly(ADP-ribose) is hydrolyzed by two enzymes, poly(ADP-ribose) glycohydrolase and phophodiesterase (Fig. 3). Poly (ADP-ribose) glycohydrolase yields ADP-ribose as the product, while phosphodiesterase yields 2 (l"-ribosyl)adenosine 5\5"-bis(phosphate) (also termed phosphoribosyl-AMP or isoADPribose) [abbreviated as Ado(P)-Rib-P] as the main degradation product. There fore, the monomer units of poly (ADP-ribose) are defined as ADP-ribose, which has pyrophosphate bonds, and Ado(P)-Rib-P, which has ribose-ribose glycosidic bonds.