By Alton Meister
Advances in Enzymology and comparable parts of Molecular Biology is a seminal sequence within the box of biochemistry, delivering researchers entry to authoritative reports of the newest discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, supplying an unequalled view of the old improvement of enzymology. The sequence bargains researchers the most recent figuring out of enzymes, their mechanisms, reactions and evolution, roles in complicated organic method, and their software in either the laboratory and undefined. each one quantity within the sequence gains contributions by means of top pioneers and investigators within the box from world wide. All articles are conscientiously edited to make sure thoroughness, caliber, and clarity.
With its wide selection of subject matters and lengthy ancient pedigree, Advances in Enzymology and comparable parts of Molecular Biology can be utilized not just through scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition through any scientist attracted to the invention of an enzyme, its houses, and its applications.
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The enzymatic nature of thrombin has been heatedly debated by adherents and opponents of the enzyme theory of blood clotting for many years. Many of these discussions degenerated to mere exercises in terminological dialectics. It is certain that the best evidence available at present supports the assumption of an enzymatic effect (221a). 6. Fibrinogen and Fibrin The liver is usually considered as the site of formation of fibrinogen in the organism. The evidence is not entirely clear-cut; but it is certain that an appreciable decrease in plasma fibrinogen takes place when the liver is excluded from the circulation or injured by poison or disease.
This agent was recognized as being associated with the phosphatides (14, 105, 227, 229) and, more particularly, with what then was called the cephalin fraction (105, 146, 147) of animal tissues. Plants, and even microorganisms, appear to contain similar substances (29). * In view of the very high particle weight of the thromboplastic protein, it should be possible to ascertain its presence in plasma by studying the behavior of plasma following centrifugation at a very high speed. Indications of the presence of a sedimentable clotting factor in plasma have been reported briefly in the literature (141).
126,435 (1938). 86. Ogston, A. , Biochem. J . , 37, 78 (1943). 87. ,Biochem. , 306, 125 (1940). 88. Pirie, N. , and Green, D. , Perspectives in Biochemistry. Marmillan, New York, and Cambridge Univ. Press, London, 1937,p. 11. 89. ,Biol. Rev. Cambridge Phil. , 15,377 (1940). 90. ,Science, 96,425 (1942). 91. Rischkov, V. , Phytopathology, 33, 950 (1943). 92. Rischkov, V. , and Sukov, K. , Compt. T e n d . acad. sci. R. ,21,265 (1938). 93. Robinson, J. , Nature, 143,923 (1939). PROPERTIES O F CERTAIN VIRUSES 94.