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Advances in Genetics, Vol. 21 by E.W. Caspari (Ed.)

By E.W. Caspari (Ed.)

This quantity in a sequence on genetics, emphasizes the range of genetic experiences. Articles disguise the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable components and the dropophila gene zeste.

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Similarly, possessing the genetic capacity to form hundreds or thousands of different P-450species does not mean that all of them would exist at any one time. At any given moment, an organism may be exposed to significant concentrations of perhaps only 10, or 50, important antigens and 10 or 50 important inducing chemicals, so that between 10 and 50 forms of immunoglobulins and induced P-450 would exist in quantities sufficient to be detected. Further work is needed to confirm or disprove this hypothesis .

Evolution apparently has generated by gene duplication, segregation, and allelic exclusion a large number of “mini-genes,” creating many small subgroups of closely homologous, yet extensively heterologous, gene segments. These segments afford large “targets” for intragenic recombination within each subgroup. Such recombination can, in turn, lead to immunoglobulin diversity in both gene number and sequence by unequal crossing-over, direct recombination, and mismatch repair. , 1978) requires no ad hoc assumptions about special enzymes and can operate in both germ line and somatic cells.

Natl. Acad. Sci. A. 72, 3623-3627. Hicks, J. , and Herskowitz, 1. (1977). Interconversion of yeast mating types. 11. Restoration of mating ability to sterile mutants in homothallic and heterothallic strains. Genetics 85, 373-393. Hildemann, W. , Johnson, I. , and Jokiel, P. L. (1979). Immunocompetence in the lowest metazoan phylum: Transplantation immunity in sponges. Science 204, 420-422. , Robinson, E. , and Appella, E. (1979). Cell-free synthesis of mouse H-2 histocompatibility antigens. Proc.

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