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Biology of Growth Factors: Molecular Biology, Oncogenes, by Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H.

By Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)

Growth elements are elaborated to regulate the expansion of cells in such physiological procedures as wound therapeutic, tissue regeneration and the immune reaction. irregular creation of those progress elements, their receptors or intracellular med!ators in their motion could lead on to ailment states together with oncogenesis. This quantity will specialise in fascinating advancements in defining the right molecular lesions that let the conversion of managed proliferative indications to neoplasia, at the attainable involvement of development components within the improvement of blood vessel illnesses as noticeable in diabetes and atherosclerosis, at the altered immune surveillance that results in autoimmunity and at the primary mechanisms during which development components sign their aim cells. we think that the contents of this quantity can assist advertise realizing of the position of those primary organic procedures and their changes in a wide selection of disorder states and stimulate new investi­ gations during this very important sector of biomedical learn. The Editors v CONTENTS views at the keep an eye on OF progress AND DIFFERENTIATION views at the Biology of progress components . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived progress issue- Its function in overall healthiness and sickness. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine R. Ross and E. W. Raines Molecular and Developmental Biology points of Fibroblast progress issue. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical houses of Human Angiogenin. . . . . . . . . . forty-one B. L. Vallee and J. F. Riordan development issue - ONCOGENE RELATIONSHIPS constitution - functionality Relationships in mobile and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . fifty five T. Pawson. P. Greer, M. Moran, K.

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Additional resources for Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications

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L. 109-134. Barnes and D. 147A;106-119. ,1986, Heparin protects basic and acidic FGF from inactivation, J. Cell. ,128:475-484. ,1981, Growth control of mammalian cells. 121. 149-171. Sci. USA, 71:4648-4652. ,1980, Growth factors and extracellular matrix, Endocrine Review, 1:201-227. 95-124. , 1978, Factors involved in the modulation of cell proliferation in vivo and in vitro: the role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells, In Vitro,14:85-118.

Biol. , 5:2523-2528. , Mergia,A. ,233:545-548. , 1986, Inhibition of endothelial cell proliferation by type B transforming growth factor: interactions with acidic and basic fibroblast factors, Biochem. Biophys. Res. , 138:476-482. ,1986, Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues, Recent Prog. in Hormone Research, 42:143-205. ,1987, Potential oncogene product related to growth factors, Nature, 326:833. ,1984, Tumorogenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region Int-2, Cell, 37:529-536.

1987), which have shown that bFGF can act as a primordial morphogen at one of the earliest embryonic stages, inducing the transformation of cells destined to be ectodermal,into mesenchymal cells. This is consistent with the in vitro properties of bFGF, which has been shown to act as mitogen as well as-morphogen for all mesenchymal cells studied to date. It is also in agreement with the ability of bFGF to support the regeneration process in lower vertebrates. One of the most popularized aspects of the in vivo biology of FGF is based on its angiogenic activity.

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