
By Harold C. Slavkin
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Extra info for Developmental Aspects of Oral Biology
Sample text
48 E. White and G. N. Trump species as compared to A cells from another species. The same holds true for B cells. Thus, if one species is immunized with A cells from another species in an attempt to elicit antibodies to A-cell-unique immunogenic determinants to be used to compare A with B, then the im munized animals cannot respond to determinants distinguishing A from B because they also contain the same molecular frameworks on their own A and B cells. Resulting antibodies theoretically cannot be directed, therefore, to A recognition molecules and generally will be found to occur only to species-specific determinants.
Mouse thymocytes also possess an organ-specific antigen, the Tla antigen, that is absent from other lymphoid cells of most strains of mice. With detailed analysis of the antigenic markers of different cell types, the developmental biologist should have further parameters to delineate characteristics of cell populations in developing systems. II. Antibodies to Inducers between Two Cell Types The role of inducers in differentiation and development remains con troversial. In experimental systems employing mesenchymal and epi thelial cells, there seems to be some inductive component or event that 3.
Wang, T. Y. (1967). /. Biol. Chem. 242, 1220. Wilkins, M. H. , and Zubay, G. ( 1963). /. Mol Biol 7, 756. Zubay, G. (1964). In "The Nucleohistones" (J. Bonner and P. ), pp. 9 5 107. Golden-Day, San Francisco, California. , and Doty, P. ( 1969). /. Mol Biol. 1, 20. CHAPTER 3 Immunological Determinants in Development EDWARD WHITE and GARY N. TRUMP I. Introduction A. General Considerations B. Terminology and Genetics of Antigens and Antibodies . C. Some Applications of Antibodies to Developmental Studies .