By David Gottlieb, Daniel R. Marshak
Stem cells are the focal point of excessive curiosity from a starting to be, multidisciplinary group of investigators with instruments for keeping apart and characterizing those elusive phone forms. This quantity, which beneficial properties contributions from a number of the world's top laboratories, presents a wide and authoritative foundation for knowing the biology of stem cells and the thrill approximately their capability for scientific exploitation. it's going to be an invaluable paintings of reference for investigators in embryology, hematology, and neurobiology, and their collaborators within the rising box of regenerative drugs.
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Additional resources for Stem Cell Biology (Cold Spring Harbor Monograph Series, Volume 40)
S. 1993. DNA polymerase α is essential for mating-type switching in fission yeast. Nature 361: 271–273. S. 1998. A novel function of the DNA repair gene rhp6 in mating-type silencing by chromatin remodeling in fission yeast. Mol. Cell. Biol. 18: 5511–5522. , and McGill C. 1982. Homothallic switching of yeast mating type cassettes is initiated by a double stranded cut in the MAT locus. Cell 31: 183–192. , and Nielsen O. 1993. The smt-0 mutation which abolishes mating-type switching in fission yeast is a deletion.
Klar gated fashion (Grewal and Klar 1996; Thon and Friis 1997). 6 x 10–4/cell division. Even more spectacularly, when cells with these states were mated and the resulting diploid was grown for more than 30 generations and then subjected to meiotic analysis, we found that each state was stable and inherited as a Mendelian epiallele of the mat region (Grewal and Klar 1996). Thus, the epigenetic state is stable in both mitosis and meiosis as a Mendelian, chromosomal marker. To explain this kind of inheritance, we advanced a chromatin replication model in which silencing occurs on both daughter chromatids by self-templating assembly of chromatin in the mat2/3 region (Grewal and Klar 1996).
Genet. 9: 325–331. N. 1992. Mating-type determination and matingtype interconversion in Saccharomyces cerevisiae. In The molecular and cellular biology of the yeast Saccharomyces (eds. W. ), p. 583–656. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. S. , Jr. 1996. Transcriptional silencing of the yeast mating-type genes. In Epigenetic mechanisms of gene expression (eds. A. 467–487. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. S. 1998. The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast.